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KMID : 0387420200310020063
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Korean Society of Oriental Neuropsychiatry
2020 Volume.31 No. 2 p.63 ~ p.76
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A Prospective Observational Study of Herbal Medicines on Depressive Disorder
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Kim Ju-Yeon
Kim Hwan
Lee Ji-Yoon
Jung Jin-Hyeong
Yang Chang-Sop
Lee Mi-Young
Jung In-Chul
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Abstract
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Objectives: The purpose of this study was to verify the clinical effects of herbal medicines on patients with depressive disorder.
Methods: A prospective observational study on patients with depressive disorder was conducted. The patients were treated with herbal medicines for eight weeks. The Korean Hamilton Depression Rating Scale (K-HDRS) was evaluated as the primary outcome and the Korean Beck’s Depression Inventory (K-BDI), Instrument on Pattern Identification for Depression, Korean Symptom Checklist-95 (KSCL-95), Insomnia Severity Index (ISI), Korean State-Trait Anxiety Inventory (STAI-K), Korean State-Trait Anger Expression Inventory (STAXI-K), EuroQol five-dimensional Questionnaire (EQ-5D), Minnesota Multi-phasic Personality Inventory-2 (MMPI-2), Heart Rate Variability (HRV) were measured as the secon-dary outcome. Adverse events were assessed for safety.
Results: A total of 35 participants were observed for 12 weeks. The K-HDRS improved significantly in four, eight, and 12 weeks and the K-BDI showed significant differences in four, and eight weeks. There were no significant improvements in other evaluation scales. Gyejibongnyeong-hwan was the most frequently and continuously prescribed, showing significant improvements of K-HDRS after eight weeks of treatment.
Conclusions: In our observational study, herbal medicine was effective for relieving the depression of patients with depressive disorder and Gyejibongnyeong-hwan showed the most significant effective-ness.
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KEYWORD
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Depressive disorder, Herbal medicine, Observational study, Gyejibongnyeong-hwan
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